UDK: 547.856.1

Synthesis of the novel acetanilide nucleic acid bases derivatives

D. V. Merezhkina, S. Yu. Kozlov, A. R. Pluzhnikova, M. O. Tuzhikova, M. S. Novikov, A. A. Ozerov

Волгоградский государственный медицинский университет, Россия, Научный центр инновационных лекарственных средств; 2 Волгоградский медицинский научный центр, Россия, лаборатория медицинской химии

Abstract

N-alkylation of nucleic bases and 5-(phenylamino)uracil with 3,5-dimethylchloroacetanilide readily proceeds in anhydrous DMF medium in the presence of potassium carbonate at room temperature. 5-(Phenylamino)uracil gives predominantly N1,N3-disubstituted alkylation product, unlike other substrates used.

Keywords

uracil, thymine, cytosine, adenine, 5-(phenylamino)uracil, chloroacetanilide

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