UDK: 616-091.8

Morphological features of iNOS expression in the hippocampus and dentate gyrus of rats in modeling of chronic alcohol intoxication

A. V. Smirnov, A. A. Zamlelov, I. N. Tyurenkov, V. I. Statsenko, L. I. Alexandrova, R. P. Samusev, V. S. Zamaraev

ФГБОУ ВО «Волгоградский государственный медицинский университет» МЗ РФ, кафедра патологической анатомии, кафедра фармакологии и фармации Института НМФО, кафедра клинической фармакологии и интенсивной терапии, кафедра анатомии человека, кафедра микробиолог

Abstract

A qualitative analysis of the expression of the iNOS biomarker in the hippocampus and dentate gyrus of rats was performed when modeling chronic alcohol intoxication. Intense iNOS expression was detected in the hippocampus and dentate gyrus of alcoholized rats, which indicates the role of NO in neurotoxicity processes through activation of the nitroxidergic system in the rat brain.

Keywords

alcohol, rat, hippocampus, dentate gyrus, iNOS, injury, alcohol intoxication

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