UDK: 616-091.8

Morphological changes of the neurons of the granular layer of the geared sign in stress-induced depression and the possibility of pharmacological correction by the new derivative of glutamin acid

M. R. Ekova, A. V. Smirnov, I. N. Tyurenkov, E. V. Volotova

Волгоградский государственный медицинский университет, кафедра патологической анатомии; Институт непрерывного медицинского и фармацевтического образования ВолгГМУ, кафедра фармакологии и фармации; Волгоградский медицинский научный центр, лаборатория морфо

Abstract

Were conducted morphometric study of changes in the granular layer of the dentate gyrus of rats at the age of 12 months when modeling depression and assessing the possibility of pharmacological correction of the revealed changes with neuroglutam. In the granular layer of the dentate gyrus, the following areas were determined: areas of nuclei, cytoplasm and pericarion of neurons, nuclear-cytoplasmic ratio, relative areas of nuclei, cytoplasm and pericarions of neurons, relative area of neuropil. In rats with experimental depression, compared with the control group, an increase in the relative area of the neuropil and a decrease in all other morphometric parameters were noted. The use of neuroglutam demonstrated a corrective effect.

Keywords

dentate gyrus, depression, stress, neuron, rat

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