UDK: 547.856.1

Synthesis of 1,3-dibenzoyl- and 3-benzoyl-6-bromoquinazoline- 2,4(1H,3H)-dione

A. A. Ozerov, M. S. Novikov, E. A. Khodes

Волгоградский медицинский научный центр, лаборатория медицинской химии

Abstract

The reaction of the 1,3-dibenzoyl derivative of 6-bromoquinazoline-2,4(1H,3H)-dione with potassium carbonate in anhydrous DMF at room temperature is accompanied by the evolution of carbon dioxide to form a highly soluble potassium salt of 3-benzoyl-6-bromoquinazoline-2,4(1H,3H)-dione and a slightly soluble potassium benzoate. In contrast to the dibenzoyl derivative of 6-methyluracil, N1-debenzoylation of the 1,3-dibenzoyl derivative of 6-bromoquinazoline- 2,4(1H,3H)-dion under the indicated conditions proceeds less selectively and partly gives the product of complete debenzoylation, 6-bromoquinazoline-2,4(1H,3H)-dione.

Keywords

6-bromoquinazoline-2,4(1H,3H)-dione, benzoylation, debenzoylation

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