UDK: 612.753

The study of the toxic effect of homocysteine thiolactone in organotypic tissue culture of bone tissue

N. A. Pasatetckaia, A. I. Lopatin, A. V. Kipenko, E. V. Lopatina

Федеральное государственное бюджетное учреждение «Северо-Западный Федеральный медицинский исследовательский центр им. В. А. Алмазова», Санкт-Петербург; Федеральное государственное бюджетное учреждение науки «Институт физиологии им. И. П. Павлова» Российск

Abstract

The change in homocysteine and homocysteine thiolactone blood level is associated with increased risk of cardiovascu- lar diseases and osteoporosis. The decrease in Na+, K+-ATPase activity detected in case of hyperhomocysteinemia. In experiments in vivo it was shown that homocysteine reduces the activity of Na+,K+-ATPase inhibiting its pump function. However, information about the physiological role of Na+,K+-ATPase in the processes of remodeling of bone tissue is limited due to methodological difficulties.

Keywords

homocysteine thiolactone, Na+,K+-ATPase, organotypic tissue culture, bone tissue explants

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