Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 615.3:547.854.4

Synthesis of 1-[4-(phenoxy)benzyl]-5-(phenylamino)uracils as potential antiviral agents

Волгоградский государственный медицинский университет, кафедра фармацевтической и токсикологической химии


Using condensation of 2,4-bis(trimethylsilyloxy)-5-(phenylamino)pyrimidines achieved by silylation from corresponding 5-(phenylamino)uracils, with 4-(phenoxy)benzyl bromide in 1,2-dichloroethane solution by boiling for 30 h we synthesized 1-[4-(phenoxy)benzyl]-5-(phenylamino)uracils containing substituents in phenylamino fragment. The yield of the target compounds was 60—74 %.


synthesis, 5-(phenylamino)uracil, N-alkylation, potential antiviral agents