Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 616.91:616.831.8-092.4

Comparative characteristics of morphological changes in the brain stem of animals with clinical signs of encephalitis in the intraperitoneal and subcutaneous route of infection with astrakhan strain of West Nile virus

A. V. Smirnov, M. V. Schmidt, V. A. Glukhov, A. M. Butenko, V. F. Larichev, N. V. Khutoretskaya

Волгоградский государственный медицинский университет, кафедра патологической анатомии, Волгоградский медицинский научный центр


Marked pathomorphological changes were revealed in the brain stem in experimental modeling of West Nile fever regardless of the route of infection. More severe degenerative changes were observed in the intraperitoneal route of infection. Comparative characteristics of the obtained results with pathomorphological changes in the brain stem of patients who died of West Nile fever bring us to an indirect conclusion that there is more pronounced similarity between these changes and those obtained on the model of intraperitoneal infection with the Astrakhan strain of West Nile virus.


pathomorphological changes, West Nile fever, brain stem