Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 617.7-003.821–053.9-06

The role of molecular mechanisms of retina pigment epithelium damage in amyloidogenesis in patients with age-related macular degeneration

V. V. Ermilov, O. V. Makhonina

Волгоградский государственный медицинский университет


The article highlights the problem of senile non-endocrine amyloidosis, which is common in the persons older than 80 years of age. Amyloidosis is understood as a multiple-factor process, but still the results of molecular and biological study of recent decades have demonstrated the leading role of the protein precursors of amyloid in disease, which has yielded new, more effective methods of treatment.


amyloidogenesis, age-related macular degeneration, pigmental epithelium of retina