UDK: 616-001.34

Study of the effect of new sulfo-derivative pyrimidine-4 (1H)-ONE on neurodegradation in chronic traumatic encephalopathy

Kirill A. Miroshnichenko, Maxim V. Chernikov, Anna A. Potapova

Пятигорский медико-фармацевтический институт – филиал Волгоградского государственного медицинского университета, Пятигорск, Россия

Abstract

This experimental work was carried out to determine the effect of the introduction of a new pyrimidine derivative on neurodegradation in conditions of chronic traumatic encephalopathy on 100 male Wistar rats. To reproduce the pathology, an installation was used that simulates the effects of an explosive wave, exposure to animals was carried out once. Choline alfoscerate and gopantenic acid acted as reference drugs. The comparison preparations and the test compound were administered once 30 min after the pathology simulation. Determination of neurodegradation markers: glial-fibrillar acid protein (GFAP) and beta-amyloid (Aβ) was carried out 1 day and 14 days after modeling pathology using solid-phase enzyme immunoassay. The results obtained indicate the presence of cerebroprotective activity of the new pyrimidine derivative.

Keywords

chronic traumatic encephalopathy, pyrimidine derivatives

Contacts

k220436@yandex.ru, https://orcid.org/0000-0002-9811-1678; m.v.chernikov@pmedpharm.ru, https://orcid.org/0000-0001-8340-1296; a4328822@yandex.ru, https://orcid.org/0000-0001-9728-6751