UDK: 544.127:546.32:547.29:542.22
N. N. Chuchkova, O. M. Kanunnikova, K. A. Pazinenko, M. V. Smetanina, O. V. Karban, O. L. Polyakova
Ижевская государственная медицинская академия, Россия; Ижевская государственная сельскохозяйственная академия, Россия; Первый Московский государственный медицинский университет им. И. М. Сеченова, Россия
The purpose of the study: to obtain mechanoactivated tautomeric forms of potassium orotate, to evaluate the physical and chemical characteristics of tautomers and the effectiveness of their action on the body of laboratory animals. Re- search methods: mechanical activation of potassium orotate in a spherical planetary mill, investigation of powders by atomic force microscopy, X-ray phase analysis, NEXAFS spectrum, and investigation of the effects of the use of pow- ders of various tautomeric forms of potassium orotate on animals. It was found that the mechanical activation of the ini- tial oxo-form during 1h led to the formation of the hydroxy-form, after 6h – the dihydroxy-form, which differs in physical and chemical properties. In animal experiments, a higher efficiency of mechanoactivated drugs (hydroxy-form > dihy- droxy-form) were found to be more effective than the original oxo-form. The obtained data can be used as a basis for clinical testing of the hydroxyl-form of orotic acid, as the most active form of the drug.
mechanical activation, potassium orotate, orotic acid tautomers, hepatopathy