UDK: 616-092.9: 615.015.35: 615.099.036.1

Synergy effect of endogenic antimicrobial and low-molecular placentary peptides in the composition of niosomal gel in treatment of burns infected by antibiotic-resistant microbe

N. I. Heralova, I. A. Bazikov, A. N. Maltsev, O. I. Sedykh, V. A. Baturin, Ramesh K. Goyal, Madhu Gupta, M. V. Rubailo, D. Yu. Gurov

ФГБОУ ВО «Ставропольский государственный медицинский университет» МЗ РФ1; Делийский государственный научно-исследовательский фармацевтический университет, Нью Дели, Индия; ГБУЗ СК «Ставропольская краевая клиническая больница»; ФГБОУ ВО «Волгоградский госу

Abstract

In experiments on rats, a model of an infected burn was created to study the effectiveness of a combination of isolated endogenous antimicrobial and low molecular weight placental peptides in a niosomal gel. In the experimental group, when applying niosomal gel with antimicrobial peptides, the linear rate of wound healing was (0,0272 ± 0,0094) mm2 / day, which significantly exceeded the indicators of the control group. The calculation of the percentage rate of wound healing correlated with the results of the relative loss of wound area: niosomal gel with antimicrobial peptides accelerated wound regeneration. This tendency was especially noted in the period from 9 to 16 days of the experiment with burns infected with Staphylococcus aureus. Based on the studies carried out in an experiment on rats, a conclusion was made about the effectiveness of niosomal gel with endogenous antimicrobial and low molecular weight placental peptides when applied twice to burns complicated by antibiotic-resistant microflora.

Keywords

endogenous antimicrobial and low molecular weight peptides, antibiotic resistance, niosomes, preclinical studies

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