UDK: 612.753

Comparative analysis of the effect of adrenoblockers in the conditions of organotypic bone tissue cultivation

N. A. Pasatetckaia, A. I. Lopatin, E. V. Lopatina

Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова, Санкт-Петербург, Национальный медицинский исследовательский центр им. В. А. Алмазова, Санкт-Петербург; «Институт физиологии им. И. П. Павлова» Российской ака

Abstract

Currently, the possibility of using adrenoblockers for the treatment and prevention of osteoporosis is actively discussed. The mechanism of osteoprotective action of adrenoblockers is poorly studied. The aim of the study was to compare the effect of metoprolol and propranolol on the growth of bone tissue cells in normal and high concentrations of epinephrine. The drugs did not directly stimulate the growth of bone tissue cells. The non-selective beta-blocker propranolol reduced bone resorption caused by high concentrations of epinephrine.

Keywords

osteoporosis, propranolol, metoprolol, β-adrenergic receptors, organotypic tissue culture

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