UDK: 616-006.61

Characterization of syndecan-1 (CD138) expression in the tumor cells and stromal fibroblasts of tongue squamous cell carcinoma

R. F. Zibirov, S. A. Mozerov

Медицинский радиологический научный центр им. А. Ф. Цыба – филиал ГБУ «Национальный медицинский исследовательский центр радиологии», Калужская область, Обнинск

Abstract

To evaluate the expression of syndecan-1 (CD138) in parenchymal cells and stromal fibroblasts of tongue squamous cell carcinoma. Оbtained results indicate that change of differentiation of squamous cell cancer of the tongue is accompanied by a change in the expression of syndecan-1 by tumor cells, and during investigation of syndecan-1 expression, it is necessary to pay attention to both the number of tumor cells with expression, and the quality (weak, moderate, strong) of expression , its heterogeneity. Expression of syndecan-1 in the stromal fibroblasts of the tongue squamous cell carcinoma is rarely detected and it is focal and weak.

Keywords

squamous tongue carcinoma, differentiation, syndecan-1

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