UDK: 616-005.4:611.813.14:616-092.9

AIF expression level in a hippocampus of rats in the experimental modeling of carotid occlusion

A. V. Smirnov, D. S. Mednikov, I. N Tyurenkov, D. V. Kurkin, E. V. Volotova, D. . Bakulin

Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ИНМФО; Волгоградский медицинский научный центр, лаборатория морфологии, иммуногистохимии и канцерогенеза

Abstract

Here we present the results of immunohistochemical study of caspase-independent marker of apoptosis AIF in a pyramidal layer of a hippocampus of rats in the carotid occlusion experimental modelling. The level of AIF expression veraciously increased in CA1 and CA3 both in the relative area of immunopositive material and in intensity of reaction. Be- sides, morphometric study demonstrates destructive and adaptive changes of pyramidal neurons, signs of both reversi- ble and irreversible neuronal injury in pyramidal layer and significant increase in the number of defective neurons within CA1 and CA3.

Keywords

hippocampus, carotid stenosis, apoptosis, AIF, rat

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