UDK: 547.854

Novel 1-benzyl and 1,3-dibenzyl 5-(phenylamino)uracil derivatives: synthesis and antiviral activity

A. I. Luganchenko, M. S. Novikov, A. A. Ozerov

Волгоградский медицинский научный центр, Лаборатория медицинской химии

Abstract

Synthesis of new potential antiviral agents as non-nucleoside inhibitors of virus-specific enzymes of pyrimidine nature, containing benzyl fragments at N1 and N3 position of the 5-(phenylamino)uracil was carried out. 1-(3-Benzoylbenzyl)-5- (phenylamino)uracil effectively suppresses the replication of various strains of human cytomegalovirus and varicella- zoster virus in HEL cell culture with the value of inhibitory concentration in the range from 1,64 to 11,14 μg/ml.

Keywords

5-(phenylamino)uracil, human cytomegalovirus, varicella-zoster virus

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