UDK: 547.856.1:615.072:543.241.8:543.554.4

Development and validation of methods of quantitative determination of substance 3-[2-oxo-2-(4-phenyl-1- piperazinyl)ethyl]quinazoline-4(3H)-one by method of potentiometric titration in a non-aqueous environment

T. A. Gendugov, A. A. Glushko, A. A. Ozerov, L. I. Shcherbakova

Пятигорский медико-фармацевтический институт – филиал ВолГМУ, кафедра неорганической, физической и коллоидной химии; Волгоградский государственный медицинский университет, кафедра фармацевтической и токсикологической химии

Abstract

The possibility of using of potentiometric titration in a nonaqueous medium for the quantitative determination of the sub- stance 3-[2-(4-phenyl-1-piperazino)-2-oxoethyl]quinazoline-4(3H)-one has been studied. The methodology for determi- nation was developed and its validation was evaluated in terms of parameters linearity, precision, correctness.

Keywords

quinazoline-4(3H)-one, quantification, titration, potentiometry, validation

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