UDK: 616-091.8

Morphological transformations in the pyramidal layer of CA1 hippocampus in the modeling of chronic alcohol intoxication and pharmacological correction by Neuroglutam

Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ; Волгоградский медицинский научный центр

Abstract

A qualitative and quantitative analysis of morphological changes in pyramidal layer of CA1 zone of hippocampus of rats was performed during simulation of chronic alcohol intoxication and pharmacological correction with Neuroglutam (beta- phenylglutamic acid hydrochloride, RGPU-135). In alcoholizated rats receiving Neuroglutam development of atrophic processes in pyramidal layer of CA1 hippocampus was less. It is assumed that the effectiveness of Neuroglutam is ac- companied by increased functional activity of neurons in pyramidal layer of CA1 hippocampus of rat.

Keywords

alcohol, rat, hippocampus, pathomorphosis, Neuroglutam

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