UDK: 615.014.21

Comparative compressibility study of tablet GML-1 mixtures obtained by wet granulation technology

E. V. Blynskaya, D. V. Yudina, K. V. Alekseyev, V. K. Alekseyev, S. V. Minaev

ФГБНУ «НИИ фармакологии имени В. В. Закусова»

Abstract

The study investigates the effect of solvent nature on the compression characteristics of wet-granulated tableting mixtures of a new anxiolytic active pharmaceutical ingredient GML-1. Laser diffraction method was used to determine mesh-size distribution of granulated tablet mixtures. Compressibility was determined using the «out-of-die» Heckel (equation 1) and Kawakita models (equation 3).

Keywords

wet granulation, compressibility, GML-1, Kawakita equation, Heckel equation, mesh-size distribution

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