UDK: 547.781

Alkylation of 2-aminobenzimidazole with anilides of chloroacetic acid

A. A. Ozerov, M. S. Novikov

Волгоградский медицинский научный центр, лаборатория медицинской химии

Abstract

The alkylation of 2-aminobenzimidazole with anilides of chloroacetic acid in anhydrous DMF at a temperature of 20– 100 °C in the presence of potassium carbonate leads to the formation of N1-substituted derivatives with the yield of 49– 74 %, and minor amounts of symmetric N1,N3-disubstituted analogues.

Keywords

2-aminobenzimidazole, chloroacetanilide, N-alkylation

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