UDK: 616-091.8

Morphological changes in areas CA1 and CA3 of the hippocampus of rats during the forced chronic alcohol abuse and pharmacological correction compounds succicard and cytrocard

A. V. Smirnov, I. N. Tyurenkov, A. A. Zamlelov, A. V. Sinelshchikova, V. V. Bagmetova, N. S. Ganzikova, I. V. Malyuschenko

Кафедра патологической анатомии ВолгГМУ, кафедра фармакологии и биофармации ФУВ ВолгГМУ; Волгоградский медицинский научный центр, лаборатория морфологии, иммуногистохимии и канцерогенеза

Abstract

Conducted quantitative analysis of pathological changes in the pyramidal layer of area CA1 and CA3 of the hippocampus of rats during the forced chronic alcohol abuse and pharmacological correction compounds Succicard and Cy- trocard. In animals receiving test compound showed signs of reverse development of compensatory-adaptive and neurodegenerative processes in the pyramidal layer of the CA1 and CA3 areas of the hippocampus, there was marked neuroprotective effect with different degree of connections and the predominance of efficiency Cytrocard according to morphometric studies, which in turn stresses the significance of the study of drugs of natural metabolites of the nervous system and their analogs.

Keywords

alcohol, rat, hippocampus, damage, reactivity, alcohol intoxication, succicard, cytrocard

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