UDK: 616-005.4:611.813.14:616-092.9

Beclin-1 expression level in a hippocampus of rats in the chronic hemocirculatory disorders experimental modelling

A. V. Smirnov, D. S. Mednikov, M. V. Schmidt, M. R. Ekova, I. N Tyurenkov, D. V. Kurkin, E. V. Volotova, D. . Bakulin

Кафедра патологической анатомии ВолгГМУ, кафедра фармакологии и биофармации ФУВ ВолгГМУ; Волгоградский медицинский научный центр, лаборатория морфологии, иммуногистохимии и канцерогенеза

Abstract

Here we present the results of immunohistochemical research of an autophagy-marker Beclin-1 in a pyramidal layer of a hippocampus of rats in the chronic hemocirculatory disorders modelling. In the research, the Beclin-1 expression level veraciously increased in CA1 and CA2 both in the relative area of im- munopositive material and in intensity of reaction. Besides, we found the tendency to strengthening of Be- clin-1 expression level in CA3. The histologic research revealed pericellular and perivascular edema, the destructive and adaptive changes of arterioles, signs of both reversible and irreversible neuronal injury in pyramidal layer.

Keywords

hippocampus, cerebrovascular diseases, autophagy, Beclin-1, rat

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