UDK: 616-091.8

Pathologic features in area CA1 of rat hippocampus after forced chronic alcoholization

I. N. Tyurenkov, A. V. Smirnov, A. A. Zamlelov, A. V. Sinelshchikova, V. V. Bagmetova, N. S. Ganzikova, I. V. Malyuschenko, L. N. Kirichenko

Волгоградский государственный медицинский университет, кафедра патологической анатомии; кафедра фармакологии и биофармации ФУВ; Волгоградский медицинский научный центр

Abstract

The qualitative analysis of pathomorphological changes in the pyramidal, molecular layers and lacunar sublayer of the CA1 zone of rat hippocampus during forced chronic alcoholization was carried out. Signs of development of compensa- tory-adaptive and neurodegenerative processes in the pyramidal, molecular layers and lacunar sublayer of the CA1 zone of the hippocampus were found in alcoholic animals, with different degrees of severity of morphological changes were revealed in the hippocampus of intact rats, which probably indicates a constitutional tendency to formation of alco- hol dependence in some animals and emphasizes the importance of taking into account constitutional features in model- ing of experimental alcohol intoxication.

Keywords

alcohol, rat, hippocampus, damage, reactivity, alcohol intoxication

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