UDK: 547.856.1

Preparative synthesis of 6-bromo – and 6,8-dibromo quinazolin-4(3H)-one derivatives

G. N. Solodunova, A. O. Volkova, A. S. Korsheninnikova, A. R. Kucherenko, E. D. Skorokhod, V. I. Tolkacheva, K. V. Turchenkova, L. V. Turchenkova

Волгоградский медицинский научный центр, лаборатория медицинской химии

Abstract

The bromination of methyl anthranilate with N-bromosuccinimide in anhydrous N,N-dimethylformamide leads to 5-bromo- or 3,5-dibromoanthranilic acid methyl ester depending on the amount of brominating agent. Further cyclization of these esters in boiling formamide gives 6-bromoquinazolin-4(3H)-one or 6,8-dibromoquinazolin-4(3H)- one with good (69–83 %) yield.

Keywords

methyl anthranilate, bromination, N-bromosuccinimide, cyclisation, quinazoline

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