Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 547.856.1

Synthesis of carboxylic acid esters – 6,8-dibromoquinazolin-4(3H)-one derivatives

G. N. Solodunova, E. A. Solodunova, A. V. Gerasimenko, V. G. Klochkov, V. L. Klochkova

Волгоградский медицинский научный центр, лаборатория медицинской химии


The alkylation of 6,8-dibromoquinazolin-4(3H)-one with esters of 2-halogencarboxylic acids in anhydrous DMF in the presence of potassium carbonate leads to corresponding esters of 2-[4-oxo-6,8-dibromoquinazolin-3(4H)-yl]carboxylic acid with good (77–82 %) yield.


6,8-dibromoquinazolin-4(3H)-one, bromoacetic acid, 2-chloropropionic acid, N-alkylation