UDK: 616-091.8

Morphological changes in the rat hippocampus in modeling chronic alcoholism

A. V. Smirnov, A. A. Zamlelov, A. V. Sinelshchikova, V. V. Bagmetova, N. S. Ganzikova, I. V. Malyuschenko, D. N. Sidorov

Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ; Волгоградский медицинский научный центр

Abstract

A qualitative and quantitative analysis of pathomorphological changes in the rat hippocampus was carried out in the modeling of chronic alcoholism. The signs of reversible and irreversible damage were revealed as maximum in the pyramidal layer of CA3, as well as signs of development of compensatory-adaptive processes with predominance of atrophy, which were most pronounced in the CA1, and the focal character of pyramidal neurons damage was revealed.

Keywords

chronic alcoholism, rat, hippocampus

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