Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 615.214.22:547.785.5

Adrenergic and serotoninergic activity of a new antimigraine compound

Ya. V. Morkovina, Yu. V. Semenova, D. A. Salikhov, D. V. Maltsev, D. S. Yakovlev

Волгоградский государственный медицинский университет, кафедра фармакологии; Волгоградский медицинский научный центр, лаборатория экспериментальной фармакологии


We studied adrenergic and serotoninergic properties of the 9-diethylaminoethyl-2-(4-methoxyphenyl)imidazo[1,2- α]benzimidazole molecule. The compound has been shown to exhibit potent serotonin-blocking activity in the isolated rat uterus and in the 5-HTP-hyperkinesis test. In vitro and in vivo studies have shown that the compound has weak adreno-blocking activity.


serotonin, 5-HT2A-receptors, α-adrenoreceptors, 5-HTP-induced hyperkinesis, reserpine-induced hypothermia, isolated organs