UDK: 615.214.22:547.785.5

A study of anxiolytic activity of new diazepinobenzimidazoles in the elevated plus maze test

A. S. Taran, D. V. Maltsev, D. S. Yakovlev, T. V. Karavaeva, Yu. O. Tkachenko, L. N. Divaeva, A. S. Morkovnik, T. A. Kuzmenko

Волгоградский медицинский научный центр, лаборатория экспериментальной фармакологии; Волгоградский государственный медицинский университет, кафедра фармакологии; Научно-исследовательский институт физической и органической химии Южного Федерального универс

Abstract

This article provides the data on anxiolytic activity of new diazepinobenzimidazoles – a combination of two privileged structures. We have shown that have the studied parameters of DAB-7 and DAB-19 (latency to enter the open arms, entries in open arms and time spent in open arms) show no significant differences as compared to Diazepam as a reference anxiolytic drug. Therefore, we can conclude the high level of anxiolytic activity of these compounds.

Keywords

benzodiazepine, benzimidazole, diazepine benzimidazole, anxiolytic, elevated plus maze

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