UDK: 616.12-005.4-085.224

Quantitative LC-MS/MS determination of valsartan and hydrochlorothiazide in human plasma

B. E. Tolkachev, A. M. Docenko, A. O. Strygina, O. V. Magnitskaya

Волгоградский государственный медицинский университет, ГБУ Волгоградский медицинский научный центр, лаборатория клинической фармакологии

Abstract

Development and validation of the highly selective and sensitive LC-MS/MS method to detect valsartan and hydrochlo- rothiazide in human plasma were performed. Mass spectrometriy detection made it possible to enhance analytical per- formance without time- and labor consuming sample preparation procedures, thus improving the overall bioanalytical productivity in the course of the bioequivalence study.

Keywords

bioanalysis, LC-MS/MS, QTRAP, valsartan, hydrochlorothiazide

Contacts