UDK: 615.31:615.252.349.7

Inhibitory activity of specific ligands for different binding sites of glycogen phosphorylase

N. I. Cheplyaeva, E. S. Vorobiev

Волгоградский государственный медицинский университет, кафедра фармакологии

Abstract

We compared the activity of glycogen phosphorylase inhibitors with different binding sites including a catalytic site, DAB (IC50 – 49,41 mcM), a purine binding site, caffeine (IC50 – 750 mcM) and quercetin (IC50 – 15,69 mcM), indole site, CP-316819 (IC50 – 1,24 mcM). Along with this, we found that inhibitors of two different binding sites (CP-316819 and caffeine) exert a synergistic effect both with a low and a high concentration.

Keywords

diabetes mellitus type 2, glycogen phosphorylase, glycogen phosphorylase inhibitors, catalytic site, purine site, allosteric AMP site, indole site

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