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Quantitative characteristics of pathological changes in endocrine pancreas in rats with experimental streptozotocin-induced diabetes

A. V. Smirnov, G. L. Snigur, A. T. Yakovlev, D. S. Mednikov, D. V. Kurkin, E. V. Volotova, L. N. Kirichenko

Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ, кафедра биологии, кафедра клинической лабораторной диагностики с курсом клинической лабораторной диагностики ФУВ; Волгоградс

Abstract

Experimental diabetes mellitus was modeled by a single intravenous injection of streptozotocin (50 mg / kg). A significant reduction in the area and perimeter of the pancreatic islets in rats with experimental streptozotocin-induced diabetes mellitus was reported. This finding allows us to use these parameters as the basic ones when characterizing the endocrine pancreas in rats with streptozotocin-induced diabetes mellitus.

Keywords

diabetes mellitus, pancreas, histopathology

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