UDK: УДК 547.856.1

ASPECTS OF 6-BROMO-2-METHYL QUINAZOLIN-4(3H)-ONE SYNTHESIS

E. A. Solodunova, M. S. Novikov, A. A. Ozerov

Волгоградский медицинский научный центр, лаборатория медицинской химии

Abstract

Unlike the non-methylated analogue, 2-methylquinazolin-4(3H)-one, bromination with elemental bromine takes place at the methyl group and does not affect the heterocyclic aromatic nuclei. 6-bromo-2-methylquinazolin-4(3H)-one was synthesized with a yield of 55% by heating the methyl ester 2-acetylamino-5-bromobenzoic acid with ammonium hydroxide.

Keywords

quinazoline, bromination, N-bromosuccinimide, cyclisation.

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