UDK: УДК 612.084
N. I. Chepljaeva, D. A. Aleshin, E. S. Vorobiev
Волгоградский государственный медицинский университет, кафедра фармакологии
A model of obesity and insulin resistance induced by high-fat diet in rats was simulated. We have provided evidence that the antidiabetic drug of metformin reduces the severity of obesity and insulin resistance, which makes it possible to use a high-fat diet to test compounds with a similar mechanism of action.
diabetes mellitus type 2, insulin resistance, high-fat diet, obesity, metformin.