UDK: УДК 615.3:547.856.1

SYNTHESIS AND PSYCHOPHARMACOLOGICAL PROPERTIES OF 3-(2-OXOPROPYL) QUINAZOLIN-4 (3H) HYDRAZONE

E. G. Glukhova, O. V. Ivanova, G. N. Solodunova

Волгоградский медицинский научный центр, лаборатория медицинской химии

Abstract

3-(2-oxopropyl)quinazolin-4(3H)-on hydrazone was synthesized by alkylation of quinazolin-4(3H)-on with chloroacetone followed by the condensation with hydrazine. The compound enhanced the hypnotic effect of sodium thiopental and reduced the convulsive effect of picrotoxin.

Keywords

qiunazoline, chloroacetone, alkylation, hydrazone, thiopental, picrotoxin.

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