UDK: УДК 661.98+616.379-008.64-092.4:616-001.4-003.9

THE ROLE OF THE NO-SYSTEM IN THE MORPHOGENESIS OF SKIN WOUND HEALING IN DIABETES MELLITUS

A. V. Smirnov, N. G. Panshin, A. A. Slietsans, E. V. Lomkina

Волгоградский государственный медицинский университет, кафедра фармакологии и биофармации ФУВ, кафедра патологической анатомии, ГБУ «Волгоградский медицинский научный центр»

Abstract

The morphology of wound healing in rats with diabetes mellitus and simulated wounds induced by NO-system blockade was analyzed. The study demonstrated the effects of the blockade of constitutive and inducible NO-synthases on the histomorphological features of wound healing process. The role of NO-system in mechanisms of wound healing processes in rats with experimental diabetes was identified.

Keywords

diabetes, wounds, nitric oxide, aminoguanidine, L-NAME.

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