UDK: УДК 615.3:547.856.1

SYNTHESIS AND PSYCHOPHARMACOLOGICAL PROPERTIES OF HYDRASONE OF 3-(2-OXOPROPYL)QUINAZOLIN-4(3H)-ON

E. G. Glukhova, O. I. Ivanova, G. N. Solodunova

Волгоградский медицинский научный центр, лаборатория медицинской химии

Abstract

Hydrazone of 3-(2-oxopropyl)quinazolin-4(3H)-on was synthesized by alkylation of quinazolin-4(3H)-on with chloroacetone followed by condensation with hydrazine. The compound enhanced the hypnotic effect of sodium thiopental and reduced the convulsive effect of picrotoxin.

Keywords

qiunazoline, chloroacetone, alkylation, hydrazone, thiopental, picrotoxin.

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