UDK: УДК 615.015:547.77

EVALUATION OF IN VITRO ANTIGLYCATION ACTIVITY OF NOVEL SUBSTANCES

V. A. Kuznetsova, O. A. Solovyova, A. I. Matsevich, A. A. Spasov

Волгоградский государственный медицинский университет, кафедра фармакологии

Abstract

A glycation reaction was reproduced in vitro. Aminoguanidine, a well-known nonenzymatic glycosylation inhibitor,demonstrated a dose-dependent antiglycation effect. The results of the experiment have shown that this model can be used to search for new Maillard reaction inhibitors.

Keywords

antiglycation activity, aminoguanidine, diabetes mellitus.

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