UDK: УДК 574.785.5:616.379-008.64
A. S. Taran, N. I. Cheplyaeva
Волгоградский государственный медицинский университет, кафедра фармакологии
The objective of this study was to assess the effect of vildagliptin and sitagliptin on the activity of dipeptidylpeptidase-4 by the methods of spectrophotometry and fluorometry using blood plasma and recombinant enzyme. The study showed that both methods can be used for screening substances with dipeptidylpeptidase-4.
dipeptidylpeptidase-4 inhibiting activity, sitagliptin, vildagliptin, hypoglycemic drugs.