UDK: УДК 616.091.8:616.-092.9

MORPHOLOGICAL CHANGES IN VENTRAL HIPPOCAMPUS OF ADULT RATS UPON PROLONGED EXPOSURE TO COMBINED STRESS

A. V. Smirnov, M. V. Schmidt, M. R. Ekova, D. S. Mednikov, D. D. Borodin, I. N. Tyurenkov

Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ, лаборатория морфологии, иммуногистохимии и канцерогенеза ВНМЦ

Abstract

After exposure to chronic stress combined with removable multi-modal stressors (noise, vibration, pulsating bright light) on the stochastic scheme, with restraints and temperature ranges within 20–22 °С to 25–27 °С in animals after 30-minute sessions during seven days, in the ventral hippocampus of adult rats (12 months) we revealed marked signs of neuronal damage in the pyramidal layer of CA3 field, as well as signs of impaired hemodynamic changes in the microvasculature.

Keywords

hippocampus, neuron, rat, stress.

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