UDK: УДК 615.3:547.854.4

SYNTHESIS OF 1-[3-(PHENOXY)BENZYL]-5-(PHENYLAMINO)URACIL DEIVATIVES AS POTENTIAL INHIBITOR OF HEPATITIS C VIRUS REPRODUCTION

Волгоградский государственный медицинский университет, кафедра фармацевтической и токсикологической химии

Abstract

Using condensation of 2,4-bis(trimethylsilyloxy)-5-(phenylamino)pyrimidines achieved by silylation from corresponding 5-(phenylamino)uracils, with 3-(phenoxy)benzyl bromide in 1,2-dichloroethane solution by boiling we prepared 1-[3-(phenoxy)benzyl]-5-(phenylamino)uracils containing substituents in the phenylamino fragment. The yield of target compounds was 61—82 %.

Keywords

synthesis, 5-(phenylamino)uracil, N-alkylation, potential inhibitor of hepatitis C virus reproduction.

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