UDK: 615.761:616.1-092.9

Amiloride effect on the activity of platelet NA+/H+-exchanger

N. A. Gurova, A. S. Pitersen, V. Y. Fedorchuk, D. V. Kosolapova

Волгоградский государственный медицинский университет, кафедра фармакологии

Abstract

It was determined that amiloride inhibited platelet Na+/H+-exchange in dose-dependent manner and IC50 was 1,23 x 10^-6 M/L. Acute toxicity of amiloride was investigated in mice after i. p. administration, and LD50 amounted to 35 mg/kg. Conditional therapeutic index of 106,1 units was calculated.

Keywords

Na+/H+-exchanger, platelets, amiloride, LD50

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