Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 615.015:615.45:612.115

Investigetion of antithrombotic and thrombolytic activity of substance SBT-119 on experimental in vitro model (Gorog Thrombosis Test)

T. M. Bukatina, D. S. Yakovlev, A. A. Spasov, K. Ph. Suzdalev

Волгоградский государственный медицинский университет, кафедра фармакологии


We studied in vitro antithrombotic and thrombolytic activity of substance Sbt-119 with P2Y1-antagonistic properties in a native blood sample of rats. As to its occlusion time, the compound surpasses other agents of comparison, ticlopidin (р < 0, 05) and clopidogrel. Substance Sbt-119 has no influence on thrombolysis.


P2Y1-antogonistic, antithrombotic activity, thrombolytic activity, platelet activation, aggregation, coagulation, occlusion, lysis, indole, Gorog Thrombosis Test, Global Thrombosis Test, GGT Gorog Thrombosis Test, ticlopidin, clopidogrel