UDK: 615.015:615.45:612.115

Investigetion of antithrombotic and thrombolytic activity of substance SBT-119 on experimental in vitro model (Gorog Thrombosis Test)

T. M. Bukatina, D. S. Yakovlev, A. A. Spasov, K. Ph. Suzdalev

Волгоградский государственный медицинский университет, кафедра фармакологии

Abstract

We studied in vitro antithrombotic and thrombolytic activity of substance Sbt-119 with P2Y1-antagonistic properties in a native blood sample of rats. As to its occlusion time, the compound surpasses other agents of comparison, ticlopidin (р < 0, 05) and clopidogrel. Substance Sbt-119 has no influence on thrombolysis.

Keywords

P2Y1-antogonistic, antithrombotic activity, thrombolytic activity, platelet activation, aggregation, coagulation, occlusion, lysis, indole, Gorog Thrombosis Test, Global Thrombosis Test, GGT Gorog Thrombosis Test, ticlopidin, clopidogrel

Contacts