Volgograd Journal of Medical Research
Quarterly Journal of Science and Practice

UDK: 616.379-008.64:616-076:006.05

Comparative aspects of changes of ultrastructural islet pancreatic islets in experimental diabetes mellitus

G. L. Snigur, A. V. Smirnov, M. V. Schmidt, M. J. Pocheptsov, M. P. Voronkova

Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии, Волгоградский медицинский научный центр, лаборатория морфологии и иммуногистохимии


In male rats in alloxan-, streptozotocin-induced experimental diabetes mellitus of immune characteristics and ultrastructural changes of pancreatic islets cells were studed. In alloxan-induced experimental diabetes mellitus revealed necrobiotic changes in b-endocrine cells. The development of experimental streptozotocin-induced and immunodependent diabetes mellitus accompanied by a necrobiotic processes and apoptosis in b-cells of islets of Langerhans of varying degrees of severity.


b-cells, diabetes mellitus, alloxan, streptozotocin