UDK: 615.3:547.854.4

Antiviral agents. III. Synthesis of new 1-benzyl-3-acetanilide derivatives of uracil

Paramonova M. P., Babkov D. A., Ozerov A. A., Novikov M. C., Solodunova G. N.

Кафедра фармацевтической и токсикологической химии ВолгГМУ, лаборатория фармацевтической химии ВНЦ РАМН

Abstract

Processing of 1-benzyl uracil with chloroacetanilide containing different substituents in the aromatic cycle we performed synthesis of new derivatives. The yield of target compounds amounted to 73—96 %. Physico-chemical and spectral properties of the synthesized compounds were studied. These compounds appear to be potential anti-HIV-1 and anti-CMV agents.

Keywords

synthesis, benzyl uracil, N-alkylation, potential antiviral agents

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