UDK: 615.3:547.854.4

Antiviral agents. I. Synthesis of 1-[omega-(3,5-dimethylphenoxy)alkyl]-derivatives of uracil

D. A. Babkov, M. P. Paramonova, A. A. Ozerov, M. S. Novikov

Кафедра фармацевтической и токсикологической химии ВолгГМУ, лаборатория фармацевтической химии ВНЦ РАМН

Abstract

Condensation of equimolar quantities of 2,4-bis(trimethylsilyloxy)pyrimidine and 1-bromo-omega-(3,5-dimethylphenoxy)alkanes led to 1-[omega-(3,5-dimethylphenoxy)alkyl]uracil derivatives. The yields of target compounds amounted to 68—80 %. Physico-chemical and spectral properties of the synthesized compounds were studied. These compounds appear to be potential anti-HIV-1 agents.

Keywords

synthesis, uracil, 2,4-bis(trimethylsilyloxy)pyrimidines, potential antiviral agents

Contacts